The most frequent complications of diabetes mellitus are Diabetic Foot Ulcers (DFU), which has a risk of death 2.5 times compared to those without DFU. More than half of them have problems with infection (Diabetic Foot Infections). The Research wound washing to control diabetic wound infections originating from phytopharmaca using tropical natural resources such as red betel has not developed. They are a tropical plant that has many benefits. The washing the wound with irrigation and swab techniques using red betel 20% effectively reduces the total number of bacteria with diabetic ulcer isolates in white mice alloxan-induced. It reduces staphylococcus growth aureus at concentrations of 10%, 20%, 40%, 80%, 100%. This study aimed to determine the effectiveness of wound irrigation red betel 20% and 40% of the bacterial rate in DFI patients. This study used a quasi-experiment with pre-posttest control group design two treatment groups where bacterial samples were taken before and after irrigation using 20% and 40% red betel extracts while the control group used 0.9% sodium chloride. Sampling using consecutive sampling with a large sample of 10 respondents, the total sample swab is 20 samples. Wilcoxon test was used as a different test in each group showing a group. The results showed that the Wilcoxon test was used as a different test in each group showing a group of 20% p-value 0,109, group 40% p-value 0,109 and a dick group p-value 0,180. There was a decrease in the number of bacteria after irrigation betel leaf extract in all groups. The 40% betel extract irrigation group showed an average reduction in bacterial numbers. The DFI wound had an average difference in all groups but was not significant.

Mayusef Sukmana has completed his master of degree at the age of 49 years from Mulawarman University, Indonesia. He is the head of nursing laboratory department of Faculty of Medicine, Mulawarman University, Indonesia. He has over 59 publications that have been cited over 151 times, and his publication h-index is 6. He has been serving as an editorial board member of several reputed journals.